Treatment-Resistant Depression

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"If you struggle with treatment-resistant depression, there's a different choice to turn to.
If you"ve tried two or more antidepressants of adequate dose and duration and are still struggling with depressive symptoms, talk to your healthcare provider to see if you may have treatment-resistant depression. SPRAVATO works differently than other medications for treatment-resistant depression. Today"s most commonly used oral antidepressants are thought to treat depression by increasing levels of neurotransmitters (serotonin, norepinephrine and dopamine) in areas of the brain that affect mood. SPRAVATO targets the N-methyl-D-aspartate (NMDA) receptor and is believed to work differently than currently available oral antidepressants. The exact way that SPRAVATO works is unknown. SPRAVATO is taken with an oral antidepressant.
In studies of patients with major depressive disorder and active suicidal thoughts or actions, those who took and an oral antidepressant experienced a greater reduction of depressive symptoms at 24 hours compared to those who received a placebo plus an oral antidepressant.* Further reductions were seen consistently through four weeks (25 days) of treatment, so it is important to follow the treatment plan that you and your healthcare provider have made. Not all patients will respond to SPRAVATO."

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