"As a first-time donor, a staff member will greet you at the front desk and check your required documents. You will watch a brief educational video, take a free health screening and answer a medical questionnaire to assure safety, then you can begin donating plasma if you are determined suitable. Please allow for up to two hours for your first visit.fter a successful plasma donation, you will be compensated. You can return for your second donation after 48 hours. For a more comprehensive explanation of what to expect as a first-time donor, read more about the requirements to donate plasma."